Hypertonic Saline for Perioperative Fluid Management

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Hypertonic saline for perioperative fluid management.

BACKGROUND Fluid excess may place patients undergoing surgery at risk for various complications. Hypertonic saline (HS) maintains intravascular volume with less intravenous fluid than isotonic salt (IS) solutions, but may increase serum sodium. OBJECTIVES To determine the benefits and harms of HS versus IS solutions administered to patients undergoing surgery. SEARCH STRATEGY We searched th...

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IN this issue of ANESTHESIOLOGY, Rozet et al. present the findings of a comprehensive study comparing two hyperosmolar agents, hypertonic saline (HS) and mannitol, for brain relaxation during craniotomy. This work calls into question whether sufficient information is now available to advocate substitution of mannitol with HS to promote brain relaxation during routine craniotomy. It was discover...

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ژورنال

عنوان ژورنال: Anesthesia & Analgesia

سال: 2010

ISSN: 0003-2999

DOI: 10.1213/ane.0b013e3181d5daf8